The people of the Moluccas used to plant a clove tree to celebrate the birth of a child and would wear a necklace of cloves as a protection from evil spirit and illness. Strong in aroma and hot and pungent in taste, cloves are used to flavour many foods, particularly meats and bakery products; in Europe and the USA the spice is a characteristic flavouring in Christmas holiday fare, such as wassail and mincemeat. The name clove is believed to be derived from the French word clou meaning nail due to the appearance of this spice. As early as 200 BC, envoys from Java to the Han-dynasty court of China brought cloves that were customarily held in the mouth to perfume the breath during audiences with the emperor. During the late Middle ages, cloves were used in Europe to preserve, flavour, and garnish food. Clove cultivation was almost entirely confined to Indonesia, and in the early 17th century the Dutch eradicated cloves on all islands except Amboina and Ternate in order to create scarcity and sustain high prices. In the latter half of the 18th century the French smuggled cloves from the East Indies to Indian Ocean islands and the New World, breaking the Dutch monopoly.

The clove oil is used to prepare microscopic slides for viewing and is also a local anesthetic for toothaches. It is a strong antiseptic and preservative. It is used to treat flatulence, colic, indigestion and nausea. Eugenol is used in germicides, perfumes and mouthwashes, in the synthesis of vanillin, and as a sweetener or intensifier.